Identification of novel class of Triazolo-Thiadiazoles as potent inhibitors of human Heparanase and their anticancer activity

Baburajeev, C. P. and Mohan, C. D. and Shobith, R. and Mason, Daniel J. and Fuchs, Julian E. and Bender, Andreas and Barash, Uri and Vlodavsky, Israel and Basappa and Rangappa, K. S. (2017) Identification of novel class of Triazolo-Thiadiazoles as potent inhibitors of human Heparanase and their anticancer activity. BMC Cancer, 17 (1). p. 235. ISSN 1471-2407

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Official URL: https://doi.org/10.1186/s12885-017-3214-8

Abstract

Expression and activity of heparanase, an endoglycosidase that cleaves heparan sulfate (HS) side chains of proteoglycans, is associated with progression and poor prognosis of many cancers which makes it an attractive drug target in cancer therapeutics.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: MUL SWAPNA user
Date Deposited: 25 Jun 2019 05:35
Last Modified: 29 Jun 2019 05:07
URI: http://eprints.uni-mysore.ac.in/id/eprint/3782

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