Base catalyzed reaction of ethyl thioglycolate with β-aryl-β-(methylthio) acroleins: a general method for the synthesis of 2-carbethoxy-5-substituted/4,5-annulated thiophenes in high overall yields

Byre Gowda, G. and Pradeepa Kumara, C. S. and Ramesh, N. and Sadashiva, M. P. and Junjappa, H. (2016) Base catalyzed reaction of ethyl thioglycolate with β-aryl-β-(methylthio) acroleins: a general method for the synthesis of 2-carbethoxy-5-substituted/4,5-annulated thiophenes in high overall yields. Tetrahedron Letters, 57 (8). 928 - 931.

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Abstract

(Methylthio) acroleins 1a–m were shown to be stable unlike their counterpart the chloroacroleins and their efficacy as 1,3-dielectrophilic properties have now been examined successfully in this work. They are shown to react with ethyl thioglycolate in the presence of anhydrous potassium carbonate in boiling ethanol to yield the corresponding 5-substituted/4,5-annulated-2-carbethoxy thiophenes in 70–80 overall high yields.

Item Type:	Article
Uncontrolled Keywords:	Ethyl thioglycolate, Annulated thiophene, Methylthio, Chloroacroleins, Carbethoxy
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Manjula P Library Assistant
Date Deposited:	24 Jun 2019 10:39
Last Modified:	24 Jun 2019 10:39
URI:	http://eprints.uni-mysore.ac.in/id/eprint/3760

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