Metal complexes of ONO donor Schiff base ligand as a new class of bioactive compounds; Synthesis, characterization and biological evolution

Kumar Naik, K. H. and Selvaraj, S. and Naik, N. (2014) Metal complexes of ONO donor Schiff base ligand as a new class of bioactive compounds; Synthesis, characterization and biological evolution. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 131. pp. 599-605. ISSN 1386-1425

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Present work reviews that, the synthesis of (E)-N�-((7-hydroxy-4- methyl-2-oxo-2H-chromen-8-yl)methylene)benzohydrazide L ligand and their metal complexes. The colored complexes were prepared of type M2+LX 2, where M2+ = Mn, Co, Ni, Cu, Sr and Cd, L = (7-hydroxy-4-methyl-2-oxo-2H-chromen-8-yl)methylene)benzohydrazide, X = Cl -. Ligand derived from the condensation of 8-formyl-7-hydroxy-4- methylcoumarin and benzohydrazide in the molar ratio 1:1 and in the molar ratio 1:2 for metal complexes have been prepared. The chelation of the ligand to metal ions occurs through the both oxygen groups, as well as the nitrogen atoms of the azomethine group of the ligand. Reactions of the Schiff base ligand with Manganese(II), Cobalt(II), Nickel(II), Copper(II), Strontium(II), and Cadmium(II) afforded the corresponding metal complexes. The structures of the obtained ligand and their respective metal complexes were elucidated by infra-red, elemental analysis, Double beam UV-visible spectra, conductometric measurements, magnetic susceptibility measurements and also thermochemical studies. The metal complex exhibits octahedral coordination geometrical arrangement. Schiff base ligand and their metal complexes were tested against antioxidants, antidiabetic and antimicrobial activities have been studied. The Schiff base metal complexes emerges effective α-glucosidase inhibitory activity than free Schiff base ligand.

Item Type: Article
Uncontrolled Keywords: human, Polyols, chemistry, Humans, synthesis, metabolism, antioxidant, Antioxidants, Chlorine compounds, Anti-microbial activity, Coordination Complexes, coordination compound, Anti-oxidant activities, Fungi, bacterium, Bacteria, fungus, microbial sensitivity test, Microbial Sensitivity Tests, Complexation, Ligands, Metal complexes, Metal ions, Metals, drug effects, Heavy, heavy metal, Schiff base, Bacterial Infections, Manganese, ligand, Agents, Mycoses, alpha glucosidase, Functional groups, alpha-Glucosidases, Biology, Chelation, Conductometric measurements, Geometrical arrangements, glycosidase inhibitor, Glycoside Hydrolase Inhibitors, Inhibitory activity, Magnetic susceptibility, Magnetic susceptibility measurements, Octahedral coordination, Schiff Bases, Schiff-base ligands
Subjects: B Life Science > Zoology
C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Department of > Zoology
Depositing User: Arshiya Kousar Library Assistant
Date Deposited: 27 Jun 2019 07:34
Last Modified: 27 Jun 2019 07:34

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