Hemshekhar, M. and Thushara, Ram M. and Chandra Nayaka, S. and Sherman, Larry S. and Kemparaju, K. and Girish, K. S. (2016) Emerging roles of hyaluronic acid bioscaffolds in tissue engineering and regenerative medicine. International Journal of Biological Macromolecules, 86. 917 - 928.
Full text not available from this repository. (Request a copy)Abstract
Hyaluronic acid (HA), is a glycosaminoglycan comprised of repeating disaccharide units of N-acetyl-d-glucosamine and d-glucuronic acid. HA is synthesized by hyaluronan synthases and reaches sizes in excess of 2MDa. It plays numerous roles in normal tissues but also has been implicated in inflammatory processes, multiple drug resistance, angiogenesis, tumorigenesis, water homeostasis, and altered viscoelasticity of extracellular matrix. The physicochemical properties of HA including its solubility and the availability of reactive functional groups facilitate chemical modifications on HA, which makes it a biocompatible material for use in tissue regeneration. HA-based biomaterials and bioscaffolds do not trigger allergies or inflammation and are hydrophilic which make them popular as injectable dermal and soft tissue fillers. They are manufactured in different forms including hydrogels, tubes, sheets and meshes. Here, we review the pathophysiological and pharmacological properties and the clinical uses of native and modified HA. The review highlights the therapeutic applications of HA-based bioscaffolds in organ-specific tissue engineering and regenerative medicine.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Hyaluronic acid, Hyaluronic acid modification, Bioscaffolds, Hydrogels, Drug delivery, Nanomedicine, Tissue engineering |
| Subjects: | C Chemical Science > Biochemistry |
| Divisions: | Department of > Biochemistry |
| Depositing User: | Manjula P Library Assistant |
| Date Deposited: | 21 Jun 2019 09:37 |
| Last Modified: | 23 Dec 2020 05:58 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/3595 |
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