Zabiulla and Shamanth, N. H. G. and Bushra Begum, A. and Prabhakar, B. T. and Khanum, Shaukath Ara (2016) Design and synthesis of diamide-coupled benzophenones as potential anticancer agents. European Journal of Medicinal Chemistry, 115. 342 - 351.
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Abstract
A series of diamide-coupled benzophenone, 2-(4-benzoyl-phenoxy)-N-2-2-(4-benzoyl-phenoxy)-acetylamino-phenyl-acetamide analogues (9a-l) were synthesized by multistep reactions and all compounds were well characterized. Among the series (9a-l), compound 9k with three methyl groups at ortho position in rings A, B, and D and bromo group at the para position in ring E was selected as a lead compound by screening through multiple cancer cell types by in-vitro cytotoxic and antiproliferative assay systems. Also, the cytotoxic nature of the compound 9k resulted the regression of the tumor growth in-vivo, which could be due to decreased vascularisation in the peritoneum lining of the mice which regress the tumor growth. The results were reconfirmed in-vivo chorioallantoic membrane model which indicates a scope of developing 9k into potent anticancer drug in near future.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Benzophenone-diamide, Antiproliferation, Antiangiogenesis |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Yuvaraj college > Chemistry |
| Depositing User: | Manjula P Library Assistant |
| Date Deposited: | 21 Jun 2019 05:18 |
| Last Modified: | 19 Dec 2020 05:05 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/3569 |
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