Synthesis of benzoyl phenyl benzoates as effective inhibitors for phospholipase A(2) and hyaluronidase enzymes

Khanum, Shaukath Ara and Murari, S. K. and Vishwanath, B. S. and Shashikanth, S. (2005) Synthesis of benzoyl phenyl benzoates as effective inhibitors for phospholipase A(2) and hyaluronidase enzymes. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 15 (18). pp. 4100-4104.

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Official URL: http://dx.doi.org/10.1016/j.bmcl.2005.06.012

Abstract

Benzoylation of (hydroxy phenyl) phenyl methanone 2a-g to benzoyl phenyl benzoates 4a-g, a benzophenone analogue, was achieved in good yield. All the newly synthesized compounds were evaluated for their phospholipase A(2) E.C. 3.1.1.4] and hyaluronidase E.C. 3.2.1.35] enzyme inhibitory activity in snake venom as source and their structure activity relationship with respect to different groups is reported for the first time. The in vitro PLA(2) enzyme inhibitory activity and in vivo anti-inflammatory activity studies of benzoyl phenyl benzoates are illustrated. (c) 2005 Elsevier Ltd. All rights reserved.

Item Type: Article
Uncontrolled Keywords: phospholipase A(2) inhibitor; hyaluronidase inhibitor; benzoyl phenyl benzoates
Subjects: Physical Sciences > Chemistry
Divisions: PG Campuses > Manasagangotri, Mysore > Chemistry
Depositing User: Users 9 not found.
Date Deposited: 09 Apr 2013 09:22
Last Modified: 17 Oct 2015 11:19
URI: http://eprints.uni-mysore.ac.in/id/eprint/3509

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