Revamping the role of biofilm regulating operons in device-associated Staphylococci and Pseudomonas aeruginosa

Halebeedu, P. P. and Vijay Kumar, G. S. and Shubha Gopal (2014) Revamping the role of biofilm regulating operons in device-associated Staphylococci and Pseudomonas aeruginosa. Indian Journal of Medical Microbiology, 32 (2). pp. 112-123. ISSN 0255-0857

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Extensive use of indwelling devices in modern medicine has revoked higher incidence of device associated infections and most of these devices provide an ideal surface for microbial attachment to form strong biofilms. These obnoxious biofilms are responsible for persistent infections, longer hospitalization and high mortality rate. Gene regulations in bacteria play a significant role in survival, colonization and pathogenesis. Operons being a part of gene regulatory network favour cell colonization and biofilm formation in various pathogens. This review explains the functional role of various operons in biofilm expression and regulation observed in device-associated pathogens such as Staphylococcus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa.

Item Type: Article
Uncontrolled Keywords: human, nonhuman, biofilm, Staphylococcus aureus, development and aging, genetics, growth, transcriptome, gene expression, surface property, gene function, antibiotic resistance, Staphylococcus infection, Biofilms, Pseudomonas aeruginosa, bacterial protein, chaperone, review, alginic acid, bacterial infection, medical device, gene regulatory network, ligase, bacterial gene, Staphylococcus epidermidis, adhesin, artificial heart pacemaker, bacterial mutation, bacterial polysaccharide, bacterium adherence, catheter infection, central venous catheter, device infection, endotracheal tube, exopolysaccharide, gene locus, indwelling catheter, intrauterine contraceptive device, joint prosthesis, mechanical heart valve, n acetylglucosamine, needleless connector, operon, Operon, peritoneal dialysis catheter, prosthesis infection, Pseudomonas infection, regulator gene, sigma factor, Staphylococcus, teichoic acid, tobramycin, tympanostomy tube, urinary catheter, voice prosthesis
Subjects: B Life Science > Microbiology
Divisions: Department of > Microbiology
Depositing User: Arshiya Kousar LA
Date Deposited: 21 Jun 2019 06:03
Last Modified: 23 Aug 2019 07:14

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