Benzisoxazole: a privileged scaffold for medicinal chemistry

Rakesh, K. P. and Shantharam, C. S. and Sridhara, M. B. and Manukumar, H. M. and Qin, Hua-Li (2017) Benzisoxazole: a privileged scaffold for medicinal chemistry. Med. Chem. Commun., 8 (11). pp. 2023-2039. ISSN 2040-2511

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The benzisoxazole analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number of studies on benzisoxazole-containing compounds. The unique benzisoxazole scaffold also exhibits an impressive potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents and so on. This review examines the state of the art in medicinal chemistry as it relates to the comprehensive and general summary of the different benzisoxazole analogs, their use as starting building blocks of multifarious architectures on scales sufficient to drive human drug trials. The number of reports describing benzisoxazole-containing highly active compounds leads to the expectation that this scaffold will further emerge as a potential candidate in the field of drug discovery.

Item Type: Article
Subjects: B Life Science > Biotechnology
Divisions: Department of > Biotechnology
Depositing User: C Swapna Library Assistant
Date Deposited: 20 Jun 2019 05:24
Last Modified: 20 Jun 2019 05:24

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