Mohammed, Yasser H. E. and Prabhu, T. and Zabiulla and Vigneshwaran, V. and Prabhakar, B. T. and Khanum, Shaukath Ara (2017) The anti-invasive role of novel synthesized pyridazine hydrazide appended phenoxy acetic acid against neoplastic development targeting matrix metallo proteases. Biomedicine & Pharmacotherapy, 95. 375 - 386. ISSN 0753-3322
Full text not available from this repository. (Request a copy)Abstract
Neoplastic metastasis is a major process where tumor cells migrate from the primary tumor and colonize at other parts of our body to form secondary tumor. Cancer incidences are rising and novel anti-neoplastic compounds with new mechanism of actions are essential for preventing cancer related deaths. In the current examination, a novel series of pyridazine analogues 6a-l was synthesized and evaluated against metastatic neoplastic cells. Experimental data postulated compound 6j has potential cytotoxic efficacy with prolonged activity against various cancer cells, including A549, HepG2, A498, CaSki and SiHa cells. Moreover, compound 6j arrests the A549 migration and invasions markedly by counteracting matrix metalloproteinase (MMP)-2 and MMP-9 expressions. Also, compound 6j proved its potentiality against Dalton’s solid lymphoma progression in-vivo by abridging MVD and MMP expressions. Compound 6j interacts with MMP-2 and MMP-9 by H- bond in-silico, thereby down regulates the MMPs action in tumourigenesis. Altogether, we concluded that compound 6j down regulates MMP-2 and MMP-9 and thereby impairs metastatic cancer cell migration and invasions which can be translated into a potent anti-neoplastic agent.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Pyridazine, Metastasis, Dalton’s lymphoma, MMPs, Cancer |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Yuvaraj college > Chemistry |
| Depositing User: | C Swapna Library Assistant |
| Date Deposited: | 20 Jun 2019 04:59 |
| Last Modified: | 28 Jun 2019 09:32 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/3435 |
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