Bhat, Satish S. and Naveen, S. and Vidyanand, R. K. and Lokanath, N. K. and Kugaji, Manohar S. and Kumbar, Vijay and Bhat, Kishore (2017) Synthesis, structural characterization and biological properties of phosphorescent iridium(III) complexes. Journal of Inorganic Biochemistry, 177. 127 - 137. ISSN 0162-0134
Full text not available from this repository. (Request a copy)Abstract
Two phosphorescent cyclometalated iridium(III)-triptycenyl-1,10-phenanthroline complexes Ir(ppy)2(tpt-phen)+ (1) and Ir(bhq)2(tpt-phen)+ (2) {ppy=2-phenylpyridine, bhq=Benzohquinoline, tpt-phen=triptycenyl-1,10-phenanthroline} have been synthesized and structurally characterized. The structure of complex 2 has been studied by single crystal X-ray crystallography. The photophysical properties of complexes in a different solvent have also been investigated. The binding of complexes to the double stranded calf thymus (CT-DNA) has been investigated by spectroscopic techniques. These complexes condense originally circular plasmid DNA into particulate structures. The DNA-condensation induced by these complexes have been investigated by electrophoretic mobilty shift assay, dynamic light scattering, and fluorescence microscopy. Furthermore, the cytotoxicity of these complexes towards HeLa cells have been studied and their cellular localisation properties have been investigated by fluorescence microscopy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Iridium, Cyclometalated, DNA condensation, Non-viral vector, Fluorescent |
| Subjects: | D Physical Science > Physics |
| Divisions: | Department of > Physics |
| Depositing User: | C Swapna Library Assistant |
| Date Deposited: | 19 Jun 2019 10:00 |
| Last Modified: | 28 Jun 2019 09:21 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/3411 |
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