Spectrophotometric estimation of aripiprazole in tablets

Jayanna, B. K. and Devaraj, T. D. and Nagendrappa, G. and Nagendra Gowda (2016) Spectrophotometric estimation of aripiprazole in tablets. Indian Journal of Pharmaceutical Sciences, 78 (5). pp. 695-698.

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Official URL: http://dx.doi.org/10.4172/pharmaceutical-sciences....


A simple, sensitive and rapid spectrophotometric method has been developed for the determination of aripiprazole in pharmaceutical formulations. The proposed method is based on the oxidation of drug with N-bromosuccinimide and unreacted N-bromosuccinimide bleaches the blue color of methylene blue and is measured at 663 nm. The increase in absorbance is directly proportional to the aripiprazole concentration and obeys Beer-Lambert’s law in the range of 5-20 μg/ml. The molar absorptivity and Sandell’s sensitivity, of the method were found to be 1.4906×104 l/mol/cm, 0.0300 µg/cm2, respectively. No interference was observed from excipients commonly found in tablets.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Manjula P Library Assistant
Date Deposited: 19 Jun 2019 07:20
Last Modified: 15 Jul 2022 06:25
URI: http://eprints.uni-mysore.ac.in/id/eprint/3400

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