Jayanna, B. K. and Devaraj, T. D. and Nagendrappa, G. and Nagendra Gowda (2016) Spectrophotometric estimation of aripiprazole in tablets. Indian Journal of Pharmaceutical Sciences, 78 (5). pp. 695-698.
![[img]](http://eprints.uni-mysore.ac.in/style/images/fileicons/text.png) |
Text (Full Text)
Spectrophotometric Estimation of Aripiprazole in Tablets.pdf - Published Version Restricted to Registered users only Download (406kB) | Request a copy |
Abstract
A simple, sensitive and rapid spectrophotometric method has been developed for the determination of aripiprazole in pharmaceutical formulations. The proposed method is based on the oxidation of drug with N-bromosuccinimide and unreacted N-bromosuccinimide bleaches the blue color of methylene blue and is measured at 663 nm. The increase in absorbance is directly proportional to the aripiprazole concentration and obeys Beer-Lambert’s law in the range of 5-20 μg/ml. The molar absorptivity and Sandell’s sensitivity, of the method were found to be 1.4906×104 l/mol/cm, 0.0300 µg/cm2, respectively. No interference was observed from excipients commonly found in tablets.
| Item Type: | Article |
|---|---|
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Manjula P Library Assistant |
| Date Deposited: | 19 Jun 2019 07:20 |
| Last Modified: | 15 Jul 2022 06:25 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/3400 |
Actions (login required)
 |
View Item |
