Kulkarni, Bhuvan and Sharada, T. and Padigar, H. and Adimule, S. P. and Naveen, S. and Krishnappagowda, L. and Lokanath, N. and Kumsi, Manjunatha (2016) Synthesis, characterization, X-ray diffraction studies and biological evaluation of tert-butyl 4-(2-ethoxy-2-oxoethyl)-piperazine-1-carboxylate and tert-butyl 4-(2-hydrazino-2-oxoethyl)piperazine-1-carboxylate. Research on Chemical Intermediates, 42 (10). pp. 7375-7396. ISSN 1568-5675
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Abstract
wo derivatives of N-Boc piperazine, an ester derivative, i.e., tert-butyl4-(2-ethoxy-2-oxoethyl)-piperazine-1-carboxylate (1), and, a hydrazide derivativetert-butyl 4-(2-hydrazino-2-oxoethyl)piperazine-1-carboxylate (2) were synthesizedand were characterized by FT-IR,1H&13C NMR and LCMS spectroscopic studies.The structures of both 1 and 2 were further confirmed by single crystal X-raydiffraction analysis. The molecule of 1 is linear in shape with the ethyl acetate moietyadopting fully extended conformation, while the molecule of 2 is L-shaped with themolecule being twisted at the C10 atom. The crystal structure of 1 adopts a two-dimensional zig-zag architecture featuring C–H...O intermolecular interactions,while that of 2 features strong N–H...O hydrogen bonds and intermolecular inter-actions of the type N–H...N and C–H...N, resulting in a two-dimensional structure.Furthermore, a detailed analysis of the intermolecular interactions and crystalpacking of 1 and 2 via Hirshfeld surface analysis and fingerprint plots was performed.The antibacterial and antifungal activities of both the compounds have been studiedagainst several microorganisms, and were found to be moderately active.
| Item Type: | Article |
|---|---|
| Subjects: | C Chemical Science > Chemistry D Physical Science > Physics |
| Divisions: | Department of > Institution of Excellence |
| Depositing User: | Manjula P Library Assistant |
| Date Deposited: | 18 Jun 2019 10:55 |
| Last Modified: | 08 Jul 2022 11:38 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/3368 |
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