Synthesis of 2-(2-aroylaryloxy)methyl-oxazolines as potent analgesic and anti-inflammatory agents

Khanum, Shaukath Ara and Noor Fatima Khanum and Al-Ghorbani, Mohammed and Zabiulla (2016) Synthesis of 2-(2-aroylaryloxy)methyl-oxazolines as potent analgesic and anti-inflammatory agents. Der Pharma Chemica, 8 (4). pp. 453-461. ISSN 0975-413X

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Abstract

The synthetic strategies and characterization of some novel benzophenone derivatives carrying oxazoline ring are described using microwave irradiation technique. The compounds 2a-h, 3a-h and 4a-h were screened for their analgesic, anti-inflammatory, ulcerogenic, cyclooxygenase activities and acute toxicity. The results revealed that halo compounds 4a (48.3%), 4c (45.4%) and 4f (40.2%) displayed significant anti-inflammatory activity with low ulcerogenic activity in comparison with that of the standard drugs, aspirin (35.3%) and phenyl butazone (35.5%)

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Yuvaraj college > Chemistry
Depositing User: manjula User
Date Deposited: 14 Jun 2019 07:55
Last Modified: 14 Jun 2019 07:55
URI: http://eprints.uni-mysore.ac.in/id/eprint/3088

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