Synthesis of novel bioactive pyrazole carbothioamides and their antifungal activity studies

Chandrashekar, M. and Dileep Kumar, A. and Pavithra, G. and Renuka, N. and Ajay Kumar, K. (2016) Synthesis of novel bioactive pyrazole carbothioamides and their antifungal activity studies. Der Pharma Chemica, 8 (4). pp. 118-121. ISSN 0975-413X

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Abstract

A series of new pyrazoline carbothioamides bearing furan moiety were synthesized by simple one pot procedure. The method involves base catalyzed cyclocondensation reaction of chalcones 1a-e and thiosemicarbazide 2 in ethanol under optimum temperature. The reaction yielded the title compounds 5-aryl-3-(furan-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamides 3a-e in excellent yields. The synthesized new compounds were characterized by spectral studies and elemental analysis, and were evaluated in vitro for their antifungal susceptibility.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Yuvaraj college > Chemistry
Depositing User: manjula User
Date Deposited: 14 Jun 2019 07:38
Last Modified: 14 Jun 2019 07:38
URI: http://eprints.uni-mysore.ac.in/id/eprint/3086

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