Synthesis, antioxidant, and xanthine oxidase inhibitory activities of 5-4-2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione derivatives

Bushra Begum, A. and Muneera Begum and Ranganatha, V. L. and Prashanth, T. and Zameer, F. and Raghavendra, H. and Shaukath Ara Khanum (2014) Synthesis, antioxidant, and xanthine oxidase inhibitory activities of 5-4-2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione derivatives. Archiv der Pharmazie, 347 (4). pp. 247-255. ISSN 0365-6233

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Abstract

Xanthine oxidase (XO) is a complex metalloflavoprotein, the overproduction of which usually leads to a pathological condition called gout. The XO inhibitors may prove to be promising antigout agents. The XO generates superoxide anions and H2O2 for the self-defense system of the organism. Abnormal production of this superoxide (reactive oxygen species) is responsible for a number of complications including inflammation, metabolic disorder, cellular aging, reperfusion damage, atherosclerosis, and carcinogenesis. In this paper, we report the synthesis of N-substituted analogs of thiazolidinedione derivatives as effective and new class of XO inhibitors and also as antioxidant agents. Among all the compounds in the series, compound 2i produced relatively better activity against human milk XO (72% inhibition), which was also supported by docking studies.

Item Type:	Article
Uncontrolled Keywords:	controlled study, drug potency, drug synthesis, human, nonhuman, unclassified drug, animal, Animals, chemistry, Humans, synthesis, animal tissue, rat, Rats, antagonists and inhibitors, metabolism, molecular docking, Molecular Docking Simulation, priority journal, antioxidant, antioxidant activity, Antioxidants, enzymology, enzyme inhibition, article, reactive oxygen metabolite, Reactive Oxygen Species, lipid peroxidation, 2, DPPH radical scavenging assay, edetic acid, IC 50, xanthine oxidase, Human, allopurinol, breast milk, Milk, Xanthine Oxidase, xanthine oxidase inhibitor, enzyme inhibitor, Enzyme Inhibitors, 5 4 2 (5 ethyl pyridin 2 yl) ethoxy benzyl 2, 3 (2 bromo hexyl) 5 4 2 (5 ethyl pyridin 2 yl) ethoxy benzyl thiazolidine 2, 3 (4 bromo pentyl) 5 4 2 (5 ethyl pyridin 2 yl) ethoxy benzyl thiazolidine 2, 3 (8 bromo octyl) 5 4 2 (5 ethyl pyridin 2 yl) ethoxy benzyl thiazolidine 2, 4 5 4 2 (5 ethyl pyridin 2 yl) ethoxy] benzyl] 2, 4 dione, 4 dioxo thiazolidine 3 yl] acetic acid ethyl ester, 4 dioxo thiazolidine 3 yl] butyric acid ethylester, 4 dioxo thiazolidine 3 yl] hexanenitrile, 4 thiazolidinedione derivative, 5 4 2 (5 ethyl pyridin 2 yl) ethoxy] benzyl] 2 heptyl thiazolidine 2, 5 4 2 (5 ethyl pyridin 2 yl) ethoxy] benzyl] 3 hexyl thiazolidine 2, 5 4 2 (5 ethyl pyridin 2 yl) ethoxy] benzyl] 3 nonyl thiazolidine 2, 6 5 4 2 (5 ethyl pyridin 2 yl) ethoxy benzyl 2, Thiazolidinediones
Subjects:	C Chemical Science > Chemistry
Divisions:	Yuvaraj college > Chemistry
Depositing User:	Arshiya Kousar Library Assistant
Date Deposited:	15 Jun 2019 06:06
Last Modified:	18 Jun 2022 05:15
URI:	http://eprints.uni-mysore.ac.in/id/eprint/3077

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