Combined action of Silymarin and Celecoxib in modulating inflammatory mediators in osteoarthritis

Ashkavand, Z. and Malekinejad, H. and Vishwanath, B. S. (2014) Combined action of Silymarin and Celecoxib in modulating inflammatory mediators in osteoarthritis. Biomedicine and Preventive Nutrition, 4 (4). pp. 485-490. ISSN 2210-5239

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Inflammation is the hallmark of osteoarthritis (OA) leading to pain and disability. Objective of this investigation was to evaluate the effect of Silymarin (SMN, an antioxidant), Celecoxib (CLX, a selective COX inhibitor) and their combination on chemically induced arthritis in rats. The biochemical parameters and radiology impact of the treatment was also determined. Wistar male rats were assigned into five groups including control, OA+, OA+ CLX (100mg/kg), OA+ SMN (50mg/kg) and OA+ CLX+SMN (25mg/kg). Combined treatment returned the elevated levels of inflammatory mediators (ROS, TNF-α, ALP, COX-2) to normal levels in 14days. In the SMN+CLX treated animals significant reduction in KL grade and normal joint space narrowing was observed. X-ray radiological studies supported the biochemical findings. These findings suggest that co-administration of SMN with CLX could be an effective antiarthritic treatment which can equally abolish the arthritis associated secondary complication.

Item Type: Article
Uncontrolled Keywords: animal experiment, animal model, Article, controlled study, nonhuman, dose response, male, rat, antioxidant activity, cyclooxygenase 2, disease severity, reactive oxygen metabolite, alkaline phosphatase, alkaline phosphatase blood level, oxidative stress, protein blood level, drug activity, upregulation, drug dose comparison, tumor necrosis factor alpha, protein determination, celecoxib, silymarin, antiarthritic activity, knee osteoarthritis, knee radiography, synovial fluid level
Subjects: C Chemical Science > Biochemistry
Divisions: Department of > Biochemistry
Depositing User: Arshiya Kousar Library Assistant
Date Deposited: 15 Jun 2019 05:39
Last Modified: 15 Jun 2019 05:39

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