Synthesis and Cytotoxicity of Novel Analogues of Podophyllotoxin

Samudyata, C. P. and Sunil Kumar, P. and Rai, K. M. Lokanatha and Bharathi P. Salimath (2017) Synthesis and Cytotoxicity of Novel Analogues of Podophyllotoxin. IOSR Journal of Pharmacy and Biological Sciences, 12. pp. 56-62. ISSN 2278-3008

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We have synthesized four novel derivatives of podophyllotoxin, the chalcone derivatives namely 2-benzylidene-6,7-dimethoxy-4-phenyl-3,4-dihydro-2H-naphthalen-1-one (4a), 2-benzylidene-5,7-dichloro-6-hydroxy-4-phenyl-3,4-dihydro-2H-naphthalen-1-one(4b),andthe amino-thiazolyl derivatives namely7,8-dimethoxy-5-phenyl-4,5-dihydro-naphtha[1,2-d] thiazol-2-yl amine (5a)and 2-amino-6,8-dichloro-5-phenyl-4,5-dihydro-naphtho[1,2-d] thiazol-7-ol (5b). The aryl tetralin ring system in these compounds were attached to a fused aminothiazolyl ring or a chalcone ring. Synthesis of the tetralin ring in these podophyllotoxin derivatives was accomplished by the cyclization of the γ-hydroxyketones. These derivatives were evaluated for the induction of cytotoxicity in mouse mammary carcinoma cells in vitro. All the four compounds exhibited time dependent cytotoxicity at a concentration of 100μM when assessed by Trypan blue dye exclusion assay on Ehrlich Ascites Tumor (EAT) cells in vitro

Item Type: Article
Uncontrolled Keywords: Podophyllotoxin,Thiazolyl, Chalcone, Cytotoxicity, Ehrlich Ascites Tumor.
Subjects: B Life Science > Biotechnology
Divisions: Department of > Biotechnology
Depositing User: C Swapna Library Assistant
Date Deposited: 14 Jun 2019 05:51
Last Modified: 28 Dec 2020 07:11

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