Synthesis and Cytotoxicity of Novel Analogues of Podophyllotoxin

Samudyata, C. P. and Sunil Kumar, P. and Rai, K and Bharathi, P. Salimath (2017) Synthesis and Cytotoxicity of Novel Analogues of Podophyllotoxin. IOSR Journal of Pharmacy and Biological Sciences, 12. pp. 56-62. ISSN 2278-3008

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We have synthesized four novel derivatives of podophyllotoxin, the chalcone derivatives namely 2-benzylidene-6,7-dimethoxy-4-phenyl-3,4-dihydro-2H-naphthalen-1-one (4a), 2-benzylidene-5,7-dichloro-6-hydroxy-4-phenyl-3,4-dihydro-2H-naphthalen-1-one(4b),andthe amino-thiazolyl derivatives namely7,8-dimethoxy-5-phenyl-4,5-dihydro-naphtha[1,2-d] thiazol-2-yl amine (5a)and 2-amino-6,8-dichloro-5-phenyl-4,5-dihydro-naphtho[1,2-d] thiazol-7-ol (5b). The aryl tetralin ring system in these compounds were attached to a fused aminothiazolyl ring or a chalcone ring. Synthesis of the tetralin ring in these podophyllotoxin derivatives was accomplished by the cyclization of the γ-hydroxyketones. These derivatives were evaluated for the induction of cytotoxicity in mouse mammary carcinoma cells in vitro. All the four compounds exhibited time dependent cytotoxicity at a concentration of 100μM when assessed by Trypan blue dye exclusion assay on Ehrlich Ascites Tumor (EAT) cells in vitro

Item Type: Article
Uncontrolled Keywords: Podophyllotoxin,Thiazolyl, Chalcone, Cytotoxicity, Ehrlich Ascites Tumor.
Subjects: B Life Science > Biotechnology
Divisions: Department of > Biotechnology
Depositing User: MUL SWAPNA user
Date Deposited: 14 Jun 2019 05:51
Last Modified: 14 Jun 2019 05:51

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