Rapid ultra high performance liquid chromatographic assay of pinaverium bromide and its stability studies

Amruthraj, A. K. and Venkatesha, B. M. and Ananda, S. (2014) Rapid ultra high performance liquid chromatographic assay of pinaverium bromide and its stability studies. International Journal of Pharmaceutical Sciences Review and Research, 25 (2). pp. 62-66. ISSN 0976-044X

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Abstract

A rapid and validated stability indicating UPLC method for the determination of pinaverium bromide in bulk and formulation is developed. The selectivity of the method was confirmed by carrying out stressed study on pinaverium bromide at different conditions such as acidic, basic, oxidative, photolytic and thermal. The peak corresponding to pinaverium bromide was found to be free from degradants confirming the selectivity of the method. Further, the method was validated according to the ICH guidelines. The selectivity of the method was further confirmed by standard addition technique on pinaverium bromide in tablet. The precision and accuracy of the method are within the ICH limit.

Item Type: Article
Uncontrolled Keywords: article, validation study, limit of quantitation, drug stability, oxidation, limit of detection, ultra performance liquid chromatography, measurement accuracy, measurement precision, thermal analysis, tablet property, degradation kinetics, hydrolysis kinetics, linearity, quantitative assay, photolysis, pinaverium bromide, robustness
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Yuvaraj college > Chemistry
Depositing User: Arshiya Kousar
Date Deposited: 13 Jun 2019 11:06
Last Modified: 09 Jul 2019 11:30
URI: http://eprints.uni-mysore.ac.in/id/eprint/2912

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