The impacts of benzisoxazole derivative NS5 compound on Pro-apoptotic andAnti-angiogenic activities

Shirin Shoja Chaghervand (2016) The impacts of benzisoxazole derivative NS5 compound on Pro-apoptotic andAnti-angiogenic activities. European Academic Research, 4 (1). pp. 734-748. ISSN 2286-4822

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Abstract

The aims of this study were to investigate the effectiveness of NS5 on the process of pro-opoptotic and anti-angiogesnesis activities which was experimented on Swiss albino mice (6-8 weeks old). The researcher applied different types of methods such as: Trypan Blue Dye Exclusion Method, Acridine orange-EtBr staining assay, Protein estimation byLowry’s method, SDS–PAGE, Western blot Analysis for Flt-1 and Flk-1 Expression, and Histological analysis (H & E staining) for Micro vessel density (MVD) scoring. These methods were used to analyze NS5 on pro-opoptotic and anti-angiogenesis works. The results indicated that employing NS5 on 6-8 weeks old mice resulted in reducing in tumor growth and decreasing in body weight compared to the control mice. Therefore, NS5 could induce down regulation of Vascular Endothelial Growth Factor receptors (VEGFR). Insum, NS5 compound had noticeable antiongiogenic and pro-opoptotic impacts on Ehrlich ascites tumor (EAT) cells in vivo and it could be operated as an angiogenesis inhibitor proapoptic in nature

Item Type:	Article
Subjects:	B Life Science > Biotechnology
Divisions:	Department of > Biotechnology
Depositing User:	Manjula P Library Assistant
Date Deposited:	10 Jun 2019 06:22
Last Modified:	06 Sep 2022 06:09
URI:	http://eprints.uni-mysore.ac.in/id/eprint/2892

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