Inflammation and oxidative stress in viper bite: an insight within and beyond

Sunitha, K. and Hemshekhar, M. and Thushara, R. M. and Santhosh, M. S. and Sundaram, M. S. and Kemparaju, K. and Girish, K. S. (2015) Inflammation and oxidative stress in viper bite: an insight within and beyond. TOXICON, 98. pp. 89-97. ISSN 0041-0101

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Though systemic and local manifestations of snakebite are considered serious, the relevance of oxidative stress in viper bite pathology is largely denied. However, over the past decade, studies have provided substantial evidence for the presence of persistent oxidative stress in viper bite victims. This review aims at highlighting the disturbances in redox homeostasis soon after viper envenomation and its implications in the pathomechanism of secondary/long term complications including thrombocytopenia, hypopituitarism, infertility, renal abnormalities and persistent local tissue degradation. Both enzymatic and non-enzymatic components of viper venom play a pivotal role in bringing redox turbulence in victims. Venom-induced hemorrhage and necrosis with subsequent release of damage associated molecular pattern (DAMPs) molecules also contribute to sustained oxidative stress and inflammation. Studies have demonstrated that along with anti-venom therapy an antioxidant treatment during the early stages of viper bite and also long term treatment could help to reduce the occurrence of secondary/long term complications. Further, proper knowledge regarding the pathophysiology will allow for exploration of new avenues in the treatment of viper bite. (C) 2015 Elsevier Ltd. All rights reserved.

Item Type: Article
Subjects: C Chemical Science > Biochemistry
Divisions: Department of > Biochemistry
Depositing User: Users 19 not found.
Date Deposited: 11 Jun 2019 06:10
Last Modified: 11 Jun 2019 06:10

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