Attenuation of neuromotor deficits by natural antioxidants of decalepis hamiltonii in transgenic drosophila model of parkinson's disease

Jahromi, S. R. and Haddadi, M. and Shivanandappa, T. and Ramesh, S. R. (2015) Attenuation of neuromotor deficits by natural antioxidants of decalepis hamiltonii in transgenic drosophila model of parkinson's disease. NEUROSCIENCE, 293. pp. 136-150. ISSN 1873-7544

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Official URL: https://doi.org/10.1016/j.neuroscience.2015.02.048

Abstract

Oxidative stress is believed to be a major factor for the onset of Parkinson's disease (PD). In this study, we have investigated oxidative status in transgenic Drosophila model of PD. Our results revealed elevated levels of reactive oxygen species (ROS) and lipid peroxidation (LPO) in A30P and A53T alpha-synuclein PD model flies compared to control. We have demonstrated for the first time the ameliorating potential of natural antioxidants characterized from the roots of Dh in A30P and A53T alpha-synuclein PD model flies. Feeding of transgenic flies with aqueous Dh root extract for 21 days significantly improved their climbing ability and circadian rhythm of locomotor activity which was associated with reduction in levels of ROS and LPO and enhancement in the activities of catalase (CAT) and superoxide dismutase (SOD). Dh protected against paraquat (PQ) sensitivity in alpha-synuclein transgenic flies and delayed the onset of PD-like symptoms which appears to be mediated by suppression of oxidative stress. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

Item Type: Article
Uncontrolled Keywords: Drosophila melanogaster; Parkinson's disease model; oxidative stress; neurotoxicity; Decalepis hamiltonii; antioxidants
Subjects: B Life Science > Sericulture
Divisions: Department of > Zoology
Depositing User: Shrirekha N
Date Deposited: 06 Jun 2019 10:13
Last Modified: 06 Jun 2019 10:13
URI: http://eprints.uni-mysore.ac.in/id/eprint/2687

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