Titrimetric assay of isoniazid with perchloric acid in non-aqueous medium

Swamy, N. and Basavaiah, K. and Vinay, K. B. (2015) Titrimetric assay of isoniazid with perchloric acid in non-aqueous medium. JOURNAL OF ANALYTICAL CHEMISTRY, 70 (6). pp. 696-699. ISSN 1608-3199

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Official URL: https://doi.org/10.1134/S1061934815060179

Abstract

A rapid, simple, cost-effective, accurate and precise direct titrmetric method for the determination of isoniazid (INH) in pharmaceutical preparations has been developed and validated. The method is based on the titration of INH with 0.02 M acetous perchloric acid in glacial acetic acid using crystal violet as indicator. The method is applicable over the range of 1.5-15.0 mg INH. The validation of the method yielded good results that included precision (RSD < 3% for intra- and inter-day precision), and accuracy (relative error a parts per thousand currency sign2.6%). It was also found that the excipients in the commercial tablet preparation did not interfere with the assay and the results were comparable with the official method.

Item Type: Article
Uncontrolled Keywords: isoniazid; titrimetry; assay; non-aqueous; tablets
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Shrirekha N
Date Deposited: 06 Jun 2019 09:25
Last Modified: 06 Jun 2019 09:25
URI: http://eprints.uni-mysore.ac.in/id/eprint/2672

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