Vijay Kumar, H. and Kishore Kumar, C. and Naik, N. (2011) Synthesis of novel 3-chloro-1-(5H-dibenzb,f]azepine-5yl)propan-1-one derivatives with antioxidant activity. MEDICINAL CHEMISTRY RESEARCH, 20 (1). pp. 101-108.
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Abstract
A series of 3-chloro-1-(5H-dibenzb,f]azepine-5yl)propan-1-one derivatives (2a-k) bearing different amino acids were synthesized by base condensation reaction. 3-Chloro-1-(5H-dibenzb,f]azepine-5yl)propan-1-one(2) was obtained by N-acylation of 5H-dibenzb,f]azepine (1). All the synthesized compounds were evaluated for their potential over antioxidant activities against inhibition of lipid peroxidation by beta-carotene and linoleic acid assay and inhibition of human low-density lipoprotein (LDL) oxidation assay. Typically, compound 2 showed weak antioxidant activity, whereas coupling of different amino acids enhances the antioxidant activities based on the presence of different functional groups. Among the derivatives, compound 2d showed significant antioxidant activities followed by 2h, 2i, 2j and 2k.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 5H-dibenzb,f]azepine; 3-Chloro-1-(5H-dibenzb,f]azepine-5yl)propan-1-one; Amino acid; Antioxidant activity |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Users 23 not found. |
| Date Deposited: | 13 Jun 2019 12:57 |
| Last Modified: | 24 Dec 2019 09:21 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/2610 |
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