Synthesis of symmetrical and asymmetrical azines encompassing naphtho2,1-b]furan by a novel approach

Veena, K. and Ramaiah, M. and Vanita, G. K. and Avinash, T. S. and Vaidya, V. P. (2011) Synthesis of symmetrical and asymmetrical azines encompassing naphtho2,1-b]furan by a novel approach. E-JOURNAL OF CHEMISTRY, 8 (1). pp. 354-360. ISSN 0973-4945

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Abstract

The starting material 3-nitro-2-acetylnaphtho2,1-b] furan (2) was obtained by nitration of 2-acetylnaphtho2,1-b] furan (1), under mild condition. The compound 1 was synthesized by the reaction of 2-hydroxy-1-naphthaldehyde with chloroacetone, where in both condensation and cyclization took place in single step. The reaction of 3-nitro-2-acetylnaphtho2,1-b] furan (2) with hydrazine hydrate produced corresponding hydrazone (3) in excellent yield, which on treatment with various aromatic aldehydes under different reaction conditions resulted in the formation of symmetrical azines (4a-e) and unsymmetrical azines (5a-e). All the newly synthesized compounds have been characterized by analytical and spectral studies and were screened for antibacterial antibacterial activity against Bacillus subtilus and Alcaligenes fecalies and antifungal activity against Aspergillus nidulans, Aspergillus parasiticus and Aspergillus terrus. The Second Harmonic Generation (SHG) efficiency of some of the synthesized compounds was measured by powder technique using Nd:YAG laser.

Item Type: Article
Uncontrolled Keywords: Naphthofurans; Azines; Antibacterial activity; Antifugal activity; NLO
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: lpa venkatesh user
Date Deposited: 13 Jun 2019 12:41
Last Modified: 14 Jun 2019 05:54
URI: http://eprints.uni-mysore.ac.in/id/eprint/2608

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