Spectrophotometric determination of famotidine using sulphonphthalein dyes

Basavaiah, K. and Zenita, O. (2011) Spectrophotometric determination of famotidine using sulphonphthalein dyes. QUIMICA NOVA, 34 (5). pp. 735-742.

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Official URL: http://dx.doi.org/10.1590/S0100-40422011000500002


Four new extraction-free spectrophotometric methods have been established for the quantitation of famotidine (FMT). The methods are based on the formation of yellow ion-pair complexes between FMT and four sulphonphthalein dyes viz., bromothymol blue (method A), bromophenol blue (method B), bromocresol purple (method C) and bromocresol green (method D) in dioxane or acetone medium. The experimental variables such as reagent concentration, solvent medium and reaction time have been carefully optimized to achieve the highest sensitivity. The proposed methods were applied successfully to the determination of famotidine in tablets with good accuracy and precision and without interferences from common excipients. The results obtained by the proposed methods were compared favorably with those of the reference method.

Item Type: Article
Uncontrolled Keywords: famotidine assay; spectrophotometry; tablets
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Users 23 not found.
Date Deposited: 15 Jun 2019 10:33
Last Modified: 15 Jun 2019 10:33
URI: http://eprints.uni-mysore.ac.in/id/eprint/2594

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