Synthesis and in vitro biological activity of N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinamine derivatives

Mohana, K. N. and Mallesha, L. (2011) Synthesis and in vitro biological activity of N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinamine derivatives. BULGARIAN CHEMICAL COMMUNICATIONS, 43 (3). pp. 395-400. ISSN 1359-7345

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Abstract

A series of novel N-(5-amino-2-methylpheny1)-4-(3-pyridy1)-2-pyrimidinamine derivatives, 4(a-f) were synthesized by the reaction of N-(5-amino-2-methylpheny1)-4-(3-pyridy1)-2-pyrimidinamine with various ketones in order to determine their in vitro antimicrobial activities against clinically isolated strains. The antioxidant activity was also determined by diphenylpicrylhydrazyl (DPPH) radical scavenging assay method. The chemical structures were confirmed by elemental analyses, UV-Vis, FT-IR and H-1 NMR spectral studies. The synthesized compounds 4b, 4c and 4e showed moderate antimicrobial activity compared to standard drugs against bacterial and fungal strains tested. The compounds, 4b and 4c showed good antioxidant activity in diphenylpicrylhydrazyl (DPPH) radical-scavenging assay method.

Item Type:	Article
Uncontrolled Keywords:	N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinamine; ketones; antimicrobials; antioxidant
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Users 23 not found.
Date Deposited:	15 Jun 2019 10:06
Last Modified:	15 Jun 2019 10:06
URI:	http://eprints.uni-mysore.ac.in/id/eprint/2591

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