Antidiabetic properties of Hibiscus rosa sinensis L. leaf extract fractions on non-obese diabetic (NOD) mouse

Moqbel, Fahmi S. and Naik, P. R. and Habeeb, M. Najma and Selvaraj, S. (2011) Antidiabetic properties of Hibiscus rosa sinensis L. leaf extract fractions on non-obese diabetic (NOD) mouse. INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY, 49 (1). pp. 24-29.

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Abstract

On fractionation the ethanolic extract of H. rosa sinensis leaves, 5 fractions were obtained. Of these, fraction-3 (F(3)) and fraction-5 (F(5)) were chosen for detailed investigation on non obese diabetic (NOD) mouse to study anti-diabetic properties because they were more active than others. Serum glucose, glycosylated hemoglobin, triglyceride, cholesterol, blood urea, insulin, LDL, VLDL, and HDL were estimated. Both fractions F(3) and F(5) on oral feeding (100 and 200 mg/kg body weight) demonstrated insulinotropic nature and protective effect in NOD mice. These fractions may contain potential oral hypoglycemic agent.

Item Type: Article
Uncontrolled Keywords: Cholesterol; Glycosylated haemoglobin; H. rosa sinensis; Hyperglycemic; Insulin; VLDL
Subjects: Agriculture Biological Sciences > Zoology
University of Mysore > PG Campuses > Manasagangotri, Mysore > Agriculture Biological Sciences > Zoology
Divisions: PG Campuses > Manasagangotri, Mysore > Zoology
Depositing User: Users 1 not found.
Date Deposited: 26 Mar 2013 09:08
Last Modified: 19 Nov 2015 06:52
URI: http://eprints.uni-mysore.ac.in/id/eprint/2526

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