Development and validation of stability indicating spectrophotometric methods for determination of oxcarbazepine in pharmaceuticals

Basavaiah, K. and Rajendraprasad, N. and Cijo, M. X. and Vinay, K. B. and Ramesh, P. J. (2011) Development and validation of stability indicating spectrophotometric methods for determination of oxcarbazepine in pharmaceuticals. JOURNAL OF SCIENTIFIC & INDUSTRIAL RESEARCH, 70 (5). pp. 346-351. ISSN 0022-4456

Text (Full Text) Che_2011_Basavaiah_rajendraprasad.pdf - Published Version Restricted to Registered users only Download (76kB) | Request a copy

Abstract

Two simple, selective and stability indicating UV-spectrophotometric methods have been developed and validated for assay of oxcarbazepine (OXC) in bulk drug and in its dosage forms. Proposed methods are based on measurement of absorbance of OXC either in methanol (method A) or in acetonitrile (method B) at 254 nm. Calibration graphs are linear over 2-40 mu g ml(-1) in both methods with correlation coefficients (r) 0.9993 (method A) and 0.9999 (method B). Apparent molar absorptivity values were 6.73 x 10(3) (method A) and 6.95 x 10(3) l mol(-1) cm(-1) (method B). This study indicated that OXC was degraded in alkaline medium. Proposed methods were successfully applied to determination of OXC in tablets and results are comparable with reported method.

Item Type:	Article
Uncontrolled Keywords:	Assay; Oxcarbazepine; Pharmaceuticals; Stability indicating; UV-spectrophotometry
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Users 23 not found.
Date Deposited:	05 Jul 2019 12:11
Last Modified:	05 Jul 2019 12:11
URI:	http://eprints.uni-mysore.ac.in/id/eprint/2502

Actions (login required)

View Item