Synthesis, characterization and in vitro antiproliferative effects of novel 5-amino pyrazole derivatives against breast cancer cell lines

Raju, H. and Chandrappa, S. and Prasanna, D. S. and Ananda, H. and Nagamani, T. S. and Byregowda, S. M. and Rangappa, K. S. (2011) Synthesis, characterization and in vitro antiproliferative effects of novel 5-amino pyrazole derivatives against breast cancer cell lines. RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY, 6 (2). pp. 186-195. ISSN 1574-8928

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Official URL: DOI : 10.2174/157489211795328459

Abstract

In search of synthetic chemotherapeutic substances capable of inhibiting, retarding, or reversing the process of multistage carcinogenesis, we synthesised a series of novel 1-(4-methoxybenzyl)-3-cyclopropyl-1H-pyrazol-5-amine derivatives 9(a-h) by a nucleophilic substitution reaction and characterized by (1)H and (13)C nuclear magnetic resonance (NMR), liquid chromatography mass spectrometry (LC/MS), Fourier-transform infrared (FTIR), and elemental analysis. These novel compounds were evaluated for their efficacy in inhibiting VERO normal and MCF-7 breast cancer cells proliferation by trypan blue exclusion assay, MTT assay, (3)H] thymidine incorporation assay and DNA fragmentation analysis. Among the series, some compounds exhibited interesting growth inhibitory effects against cell lines. From the Structure-Activity Relationship studies, it has been revealed that, both novel patented compounds and therapeutic protocols of N-terminal pyrazole ring structures play key role in the antiproliferative activity.

Item Type: Article
Uncontrolled Keywords: 5-Amino pyrazole derivatives; aryl sulfonamide; breast cancer cells; cell proliferation; cyclisation; (3)H] thymidine incorporation; trypan blue exclusion assay; vero normal cells
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: lpa venkatesh user
Date Deposited: 05 Jul 2019 12:04
Last Modified: 05 Jul 2019 12:04
URI: http://eprints.uni-mysore.ac.in/id/eprint/2501

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