Application of ion-association titration for the assay of bupropion hydrochloride in pharmaceuticals

Abdulrahman, S. A. M. and Basavaiah, K. (2011) Application of ion-association titration for the assay of bupropion hydrochloride in pharmaceuticals. Chemical Industry & Chemical Engineering Quarterly, 17 (3). pp. 299-306.

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Two simple and rapid titrimetric methods are described for the determination of bupropion hydrochloride (BUPH) in pharmaceuticals. The proposed methods are based on the solvent extraction-titration of BUPH with two ion-association reagents, i.e., sodium lauryl sulphate (SLS) and tetraphenylborate (TPB). In method A, SLS was used as titrant and the titration was carried out in the presence of dilute sulphuric acid and chloroform using dimethyl yellow as indicator whereas in method B, the titrant was TPB and the titration was done in borate-phosphate buffer of pH 6.0 and 1,2-dichloroethane with tetrabromophenolphthalein ethyl ester (TBPE) as indicator. In the two-phase titrations, the proposed procedures give sharp end points as the color of the organic phase changes from yellow to pink in method A and from red-violet to yellow in method B. The methods are applicable over the ranges of 1.0-20.0 and 3.0-10.0 mg of BUPH for methods A and B, respectively. The accuracy and precision of the methods are good The methods were applied successfully to the determination of BUPH in tablets and the results were in agreement with the label claim and those of the comparison method. .

Item Type: Article
Uncontrolled Keywords: bupropion hydrochloride; ion-association titration; dimethyl yellow; tetrabromophenolphthalein ethyl ester; pharmaceuticals
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Users 23 not found.
Date Deposited: 16 Jul 2019 10:22
Last Modified: 22 Jun 2022 09:36

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