Tramadol hydrochloride-benzoic acid (1/1)

Siddaraju, B. P. and Jasinski, J. P. and Golen, James A. and Yathirajan, H. S. and Raju, C. R. (2011) Tramadol hydrochloride-benzoic acid (1/1). ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 67 (9). O2351-U414. ISSN 1600-5368

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Official URL: doi:10.1107/S1600536811032181


In the cation of the title co-crystal salt {systematic name: 2-hydroxy- 2-(3-methoxyphenyl) cyclohexylmethyl] dimethylazanium chloride-benzoic acid (1/1)}, C16H31NO2+center dot Cl-center dot C7H6O2, the N atom is protonated and the six-membered cyclohexane ring adopts a slightly distorted chair conformation. The dihedral angle between the mean planes of the benzene rings in the cation and the benzoic acid molecule is 75.5 (9)degrees. The crystal packing is stabilized by weak intermolecular O-H center dot center dot center dot Cl, N-H center dot center dot center dot Cl and C-H center dot center dot center dot pi interactions, forming a twodimensional chain network along the b axis. The benzoic acid molecule is not involved in the usual head-to-tail dimer bonding, but instead is linked to the ammonium cation through mutual hydrogen-bonding interactions with the chloride anion.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Users 23 not found.
Date Deposited: 08 Aug 2019 12:04
Last Modified: 25 Jul 2022 07:39

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