Synthesis and Antimicrobial Activity of 2-Methyl-5-nitroaniline Derivatives: A Structure-Activity Relationship Study

Mallesha, L. and Mahana, K. N. and Rakshith, D. and Satish, S. (2011) Synthesis and Antimicrobial Activity of 2-Methyl-5-nitroaniline Derivatives: A Structure-Activity Relationship Study. CHINESE JOURNAL OF CHEMISTRY, 29 (1). pp. 102-108.

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Official URL: http://dx.doi.org/10.1002/cjoc.201190034

Abstract

A series of 2-methyl-5-nitroaniline derivatives, 5a-5k and 6a-6f, were synthesized in order to determine their in vitro antimicrobial activity. The chemical structures of the synthesized compounds were confirmed by elemental analyses, UV-visible, FT-IR, H-1 NMR and C-13 NMR spectral studies. The structure-activity relationships of the synthesized compounds were also discussed. Among the synthesized compounds, 5f, 5d, 6b and 6e showed good antimicrobial activity compared to standard drugs.

Item Type: Article
Uncontrolled Keywords: 2-methyl-5-nitroaniline; aldehydes; ketones; antimicrobials
Subjects: Physical Sciences > Chemistry
Divisions: PG Campuses > Manasagangotri, Mysore > Chemistry
Depositing User: Users 1 not found.
Date Deposited: 26 Mar 2013 07:33
Last Modified: 29 Aug 2013 06:04
URI: http://eprints.uni-mysore.ac.in/id/eprint/2407

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