Two charge-transfer complexation reactions for spectrophotometric determination of pheniramine maleate using pi-acceptors

Raghu, M. S. and Basavaiah, K. (2011) Two charge-transfer complexation reactions for spectrophotometric determination of pheniramine maleate using pi-acceptors. JOURNAL OF SCIENTIFIC & INDUSTRIAL RESEARCH, 70 (10). pp. 851-858. ISSN 0970-5740

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Abstract

This study presents two simple, selective and rapid spectrophotometric methods for determination of pheniramine maleate (PAM) in pure form and in its formulations. Both methods are based on the formation of charge-transfer (CT) reaction of PAM with p-chloranilic acid (CAA) or 2,3-dichloro-5,6-dicyanoquinone (DDQ) in 1,4-dioxan-acetonitri le medium. CT complexes were quantified at 530 and 590 nm for CAA and DDQ methods, respectively. Beer's law is obeyed (conc. ranges, 12.5-200 mu g ml(-1) for CAA and 5-80 mu g ml(-1) for DDQ method), with correlation coefficients (r) of 0.9999 and 0.9991. Apparent molar absorptivities are calculated to be 1.27x10(3) and 3.06x10(3) l mol(-1)cm(-1), respectively and corresponding Sandell sensitivities are 0.281 and 0.112 mu g cm(-2). Developed methods were successfully applied for determination of PAM in tablets and injections.

Item Type: Article
Uncontrolled Keywords: Charge-transfer (CT) complexation; Pharmaceuticals; Pheniramine maleate (PAM); Spectrophotometry
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Users 23 not found.
Date Deposited: 14 Aug 2019 12:44
Last Modified: 14 Aug 2019 12:44
URI: http://eprints.uni-mysore.ac.in/id/eprint/2391

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