Antimicrobial potential of memecylon l. species from western ghats against clinical isolates of pathogenic bacteria

Bharathi, T. R. and Madhusudhan, M. C. and Kumar, P. P. M. and Nayaka, C. S. and Prakash, H. S. (2015) Antimicrobial potential of memecylon l. species from western ghats against clinical isolates of pathogenic bacteria. RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES, 6 (4). pp. 1280-1287. ISSN 0975-8585

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Abstract

To study the antibacterial efficiency of Memecylon species viz., M. umbellatum, M. malabaricum, M. wightii and M. edule. Antibacterial efficiency of Memecylon species were examined using hexane, ethyl acetate, methanol and water extracts major groups of phyto constituents were determined by chemical assays. The extracts were tested against five human pathogens Staphylococcus aureus, Bacillus subtilis, Salmonella typhi, Escherichia coli, and Pseudomonas aeruginosa using agar well diffusion method and its minimum inhibitory concentration (MIC). The extracts of different plant species showed significant activity against gram-negative bacteria compared to gram-positive bacteria, however, highest zone of inhibition and lowest inhibitory concentration was observed in the methanol extract of M. umbellatum and M. malabaricum against all the target microorganisms. The MIC for methanol extracts for different bacterial strains ranged from 3.4 to 22 mg/ml in M. umbellatum and 3.4 to 28 mg/ml in M. malabaricum, 3.2 to 28 mg/ml in M. edule and 3.4 to 28 mg/ml in M. wightii for different clinical isolates. The ethyl acetate and aqueous extracts of Memecylon species showed less antibacterial activity compared to methanol extracts whereas, no activity was observed for hexane extracts.

Item Type: Article
Uncontrolled Keywords: Memecylon species; Minimum inhibitory concentration (MIC); Phyto constituents; Antibacterial activity
Subjects: B Life Science > Biotechnology
Divisions: Department of > Biotechnology
Depositing User: Shrirekha N
Date Deposited: 04 Jun 2019 05:18
Last Modified: 04 Jun 2019 05:18
URI: http://eprints.uni-mysore.ac.in/id/eprint/2338

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