MTNR1B gene polymorphisms and susceptibility to type 2 diabetes: a pilot study in South Indians

Salman, M. and Dasgupta, S. and Cholendra, A. and Venugopal, P. N. and Lakshmi, G. L. and Xaviour, D. and Rao, J. and D'Souza, C. J. M. (2015) MTNR1B gene polymorphisms and susceptibility to type 2 diabetes: a pilot study in South Indians. GENE, 566 (2). pp. 189-193. ISSN 1879-0038

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Abstract

Type 2 Diabetes (T2D) is the major health concern in the Indian subcontinent. A genome-wide association study carried out with non-diabetic Indians showed association of MTNR1B variants with fasting glucose. MTNR1B mediates the effect of melatonin on insulin secretion. In light of the growing importance of MTNR1B in the etiology of T2D, we sought to test its association with the disease in the south Indian type 2 diabetics. Five single nucleotide polymorphisms of MTNR1B (rs10830962, rs10830963, rs3847554, rs1387153 and rs2166706) were genotyped in 346 T2D patients and 341 non-diabetic controls. None of the SNPs differed significantly between patients and controls with respect to allele and genotype frequencies. Linear regression analysis after adjustment for age, sex and BMI showed a significant positive association of rs3847554 with fasting glucose under recessive model (beta = 14.98, p = 0.012). Haplotypes constituted by minor alleles of rs3847554, rs1387153, rs2166706, rs10830963 and major allele of rs10830962 showed significant positive correlation with fasting glucose (p<0.05). Though the results obtained are suggestive of MTNR1B role in T2D etiology, they need to be confirmed with much larger sample sizes. (C) 2015 Elsevier B.V. All rights reserved.

Item Type: Article
Uncontrolled Keywords: Type 2 Diabetes; Fasting glucose; MTNR1B gene; Single nucleotide polymorphisms; South India
Subjects: B Life Science > Biotechnology
C Chemical Science > Biochemistry
Divisions: Department of > Biochemistry
Department of > Biotechnology
Depositing User: Shrirekha N
Date Deposited: 03 Jun 2019 05:50
Last Modified: 03 Jun 2019 05:50
URI: http://eprints.uni-mysore.ac.in/id/eprint/2081

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