Effect of novel benzisoxazole derivatives against ehrlich ascites carcinoma cells in swiss albino mice: cytotoxic and haematalogical studies

Chandra, S. S. P. and Mahadimane, V. P. (2015) Effect of novel benzisoxazole derivatives against ehrlich ascites carcinoma cells in swiss albino mice: cytotoxic and haematalogical studies. INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 6 (8). pp. 3606-3611. ISSN 0975-8232

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Official URL: https://doi.org/10.13040/IJPSR.0975-8232.6(8).3606...

Abstract

The present study is to investigate the cytotoxicity properties and haematological indices of synthesized molecules (S1-S4) in comparison to the standard drug 5 fluorouracil which reflects the anticancer potentials of the above molecules. Cytotoxicity studies were performed by in vitro MTT (3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl teterazolium bromide) assay. Haematological studies were done by drawing blood in the drug and synthesized molecules administered animals by retroorbital method. Haemoglobin, RBC, WBC, lymphocytes, Monocytes and Granulocytes counts were measured. All the above experiments were performed against Ehrlich ascites carcinoma (EAC) in Swiss albino mice. The percentage cytotoxicity and percentage viable cell counts revealed anticancer properties of the synthesized molecules. RBC count indicated protection of cell membrane from destruction and the WBC counts along with lymphocytes, Monocytes and granulocytes also show the immunoprotective characteristics of the novel molecules. Thus it has been concluded that the synthesized molecules (S1-S4) if supported by further molecular studies may have a promising role to play as anticancer agents.

Item Type: Article
Uncontrolled Keywords: Anticancer; Cytotoxic; EAC; MTT; WBC
Subjects: B Life Science > Environmental Science
Divisions: PG Centre Hassan > Bioscience
Depositing User: Shrirekha N
Date Deposited: 03 Jun 2019 05:23
Last Modified: 03 Jun 2019 05:23
URI: http://eprints.uni-mysore.ac.in/id/eprint/2074

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