Investigation on in vitro cytotoxic activity of a selected wild cucurbitaceae plant corallocarpus epigeaus against cancer

Bhavani, M. B. and Leelavathi, S. (2015) Investigation on in vitro cytotoxic activity of a selected wild cucurbitaceae plant corallocarpus epigeaus against cancer. INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 6 (8). pp. 3554-3557. ISSN 0975-8232

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Official URL: http://doi.org/10.13040/IJPSR.0975-8232.6(8).3554-...

Abstract

Medicinal plants have been investigated for possible anticancer effects. Corallocarpus epigaeus (Roth & willd.) cl. is an ethnobotanically important wild climber that belongs to the family Cucurbitaceae. The aim of the present study is to examine the cytotoxic activity of Corallocarpus epigaeus (Roth & willd.) cl., on two tumor cell lines. The methanolic root extract of the plant Corallocarpus epigaeus (Roth & willd.) cl. was subjected to cytotoxic activity study against two human cancer cell lines (MCF7, human breast adenocarcinoma and HT-29, human colon carcinoma) using the MTT assay. The concentration of methanolic root extract yields the IC50 value of 183.33 +/- 0.7 mu g/ml and <62.5 mu g/ml respectively for HT-29 and MCF-7 cell lines by MTT assay. The results showed that the root extract of Corallocarpus epigaeus has potential anticancer activity against MCF-7 and HT-29 human cancer cell lines.

Item Type: Article
Uncontrolled Keywords: Corallocarpus epigaeus; cytotoxicity; MTT assay; HT-29; MCF-7
Subjects: B Life Science > Botany
Divisions: Department of > Botany
Depositing User: Shrirekha N
Date Deposited: 01 Jun 2019 10:53
Last Modified: 01 Jun 2019 10:53
URI: http://eprints.uni-mysore.ac.in/id/eprint/2071

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