Krishnamurthy, B. and Vinaya, K. and Prasanna, D. S. and Raghava, B. and Rangappa, K. S. (2011) Synthesis of 2-methyl-3-(2-(piperazin-1-yl)ethyl)-6,7,8,9-tetrahydro-4H-pyrido1,2- a]pyrimidin-4-one derivatives as antimicrobial agents. LETTERS IN DRUG DESIGN & DISCOVERY, 8 (10). pp. 988-995.
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A series of novel 2-methyl-3-(2-(piperazin-1-yl)ethyl)-6,7,8,9-tetrahydro-4H-pyrido1,2- a]pyrimidin-4-one sulfonamide and carboxamide derivatives were synthesized in good yield. The synthesized compounds were characterized by H-1-NMR, FTIR and elemental analysis. All the synthesised compounds were screened for their in vitro antimicrobial activity by agar well diffusion and micro dilution method against standard strains of Gram-positive (Bacillus subtilis MTCC 121, Staphylococcus epidermidis 435), and Gram-negative (Xanthomonas campestris 7903 and Pseudomonas aeruginosa MTCC 7908) bacteria. Compound 7a and compound 8d with dichloro substitution among sulphonamide and carboxamide series respectively showed potent inhibitory activity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Acid chlorides; Antimicrobial activity; 2-Aminopyridine; Phosphorous oxychloride; Piperazine; Sulfonyl chlorides |
| Subjects: | C Chemical Science > Chemistry |
| Depositing User: | Users 23 not found. |
| Date Deposited: | 03 Jun 2019 12:39 |
| Last Modified: | 17 Dec 2019 10:22 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/2063 |
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