Melatonin inhibits snake venom and antivenom induced oxidativestress and augments treatment efficacy

Rachana Sharma, D. and Katkar, Gajanan D. and Sundaram, M. S. and Swethakumar, B. and Girish, K. S. and Kemparaju, K. (2017) Melatonin inhibits snake venom and antivenom induced oxidativestress and augments treatment efficacy. Acta Tropica, 169. pp. 14-25. ISSN 0001-706X

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Official URL: https://doi.org/10.1016/j.actatropica.2017.01.004

Abstract

Snakebite is a neglected health hazard. Its patho-physiology has largely been focused on systemicand local toxicities; whereas, venom and antivenom induced oxidative stress has long been ignored.Antivenom therapy although neutralizes venom lethality and saves many lives, remains ineffectiveagainst oxidative stress. This prompted us to complement antivenom with an antioxidant moleculemelatonin that would protect against oxidative stress and increase the efficacy of the existing snakebitetherapy. Here we show that D. russelli and E. carinatus venoms induce strong oxidative stress thatpersists even after antivenom administration in mice model. Additionally, antivenoms also induce oxida-tive stress. Polyvalent antivenom induce more oxidative stress than monovalent antivenom. Strikingly,antivenom and melatonin together not only inhibit venom and antivenom induced oxidative stress butalso significantly reduce the neutralizing antivenom dose. This study provides a therapeutic potentialfor enhancing the existing snakebite therapy. The combined treatment of antivenom + melatonin wouldprevent the upsurge of oxidative stress as well as minimize the antivenom load. Thus the investigationoffers immense scope for physicians and toxinologists to reinvestigate, design new strategies and thinkbeyond the conventional mode of antivenom therapy.

Item Type: Article
Additional Information: Unmapped bibliographic data: DA - 2017/05/01/ [EPrints field already has value set] JO - Acta Tropica [Field not mapped to EPrints]
Uncontrolled Keywords: Melatonin, Snake venom, Antivenom, Oxidative stress
Subjects: Agriculture Biological Sciences > Biochemistry
University of Mysore > PG Campuses > Manasagangotri, Mysore > Agriculture Biological Sciences > Biochemistry
Divisions: PG Campuses > Manasagangotri, Mysore > Biochemistry
Depositing User: Praveen Kumari B.L
Date Deposited: 29 Dec 2017 05:55
Last Modified: 29 Dec 2017 05:55
URI: http://eprints.uni-mysore.ac.in/id/eprint/20449

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