Synthesis of lignan conjugates via cyclopropanation: Antimicrobial and antioxidant studies

Raghavendra, K. R. and Renuka Nagamallu, K. and Kameshwar, Vivek H. and Srinivasan, Bharath and Ajay Kumar, K. and Shashikanth, Sheena (2016) Synthesis of lignan conjugates via cyclopropanation: Antimicrobial and antioxidant studies. Bioorganic & Medicinal Chemistry Letters, 26 (15). 3621 - 3625.

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Official URL: https://doi.org/10.1016/j.bmcl.2016.06.005

Abstract

Ethyl 2-(4-methoxyphenyl)-3-(thiophene-2-carbonyl)cyclopropanecarboxylates 2(a–f) and ethyl 4-aryl-7-oxo-4,5,6,7-tetrahydrobenzobthiophene-5-carboxylates 4(a–f) were synthesized by simple procedure. The synthesized new compounds were screened in vitro for their antimicrobial and antioxidant activities. The compounds 2b and 4f showed excellent antibacterial activity; while 2b and 4f showed remarkable antifungal properties. The results of antioxidant activity studies revealed that compounds 4b and 4f manifested profound antioxidant potential. The docking studies were done for the final compounds. The ADME result indicates that all these molecules possess pharmaceutical properties in the range of 95% of drugs.

Item Type: Article
Uncontrolled Keywords: Antimicrobial, Antioxidant, Lignans, MIC, Molecular docking
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: manjula User
Date Deposited: 01 Jun 2019 07:43
Last Modified: 10 Dec 2019 09:48
URI: http://eprints.uni-mysore.ac.in/id/eprint/2037

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