Effect of Hemidesmus indicus root extract on the blood glucose level in alloxan induced diabetic rats

Zarei, Mahsa and Baker, Syed and Zarei, Mehrdad (2013) Effect of Hemidesmus indicus root extract on the blood glucose level in alloxan induced diabetic rats. Journal of Microbiology and Biotechnology Research, 3 (2). pp. 64-67. ISSN 2231 –3168

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Abstract

In this study, the effect of a single dose of Hemidesmus indicus root extract (HiRe) on the blood glucose level in alloxan (150mg/kg b.w, ip) induced diabetic rates was evaluated. Blood was collected from the tail vein in rats at zero time and after drug administration in 1st, 2nd and 4th hour and 24 hour to examine the effect. HiRe at 250 and 1000mg / kg was used for the study. Glibenclamide (3mg / kg, p.o) was used as the standard drug. The study clearly showed that single dose of HiRe had significantly protected the glucose level in alloxan induced diabetic rates at 1st, 2nd and 4th hour and even after 24hr, with respect to that of control animals. The results of the study reveal that HiRe possess significant antidiabetic activity in single dose study, suggesting the potential role of this plant as antidiabetic drug. The effect was partly ascribed to the free radical scavenging activity of HiRe. Thus, we conclude that Hemidesmus indicus possesses profound beneficial effects in preventing diabetic related abnormalities by lowering the sugar level as normal.

Item Type: Article
Subjects: Agriculture Biological Sciences > Biochemistry
University of Mysore > PG Campuses > Manasagangotri, Mysore > Agriculture Biological Sciences > Biochemistry

Agriculture Biological Sciences > Biotechnology
University of Mysore > PG Campuses > Manasagangotri, Mysore > Agriculture Biological Sciences > Biotechnology

Agriculture Biological Sciences > Microbiology
University of Mysore > PG Campuses > Manasagangotri, Mysore > Agriculture Biological Sciences > Microbiology
Divisions: PG Campuses > Manasagangotri, Mysore > Biochemistry
PG Campuses > Manasagangotri, Mysore > Biotechnology
PG Campuses > Manasagangotri, Mysore > Microbiology
Depositing User: Praveen Kumari B.L
Date Deposited: 28 Oct 2017 04:53
Last Modified: 28 Oct 2017 04:53
URI: http://eprints.uni-mysore.ac.in/id/eprint/20106

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