Knockdown resistance ( kdr ) mutations in Indian anopheles stephensi (diptera: culicidae) populations

Dykes, Cherry L. and Das, Manoj K. and Eapen, Alex and Batra, Chandra P. and Ghosh, Susanta K. and Vijayan, V. A. and Mishra, Shobhna and Singh, Om P. (2016) Knockdown resistance ( kdr ) mutations in Indian anopheles stephensi (diptera: culicidae) populations. Journal of Medical Entomology, 53 (2). pp. 315-320.

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Knockdown resistance ( kdr ) in insects resulting from mutation(s) in the voltage-gated sodium channel (VGSC) gene is one of the mechanisms of resistance against DDT and the pyrethroid group of insecticides. Earlier, we reported the presence of two classic kdr mutations, i.e., L1014F and L1014S in Anopheles stephensi Liston, a major Indian malaria vector affecting mainly urban areas. This report presents the distribution of these alleles in different An. stephensi populations. Seven populations of An. stephensi from six states of India were screened for the presence of two alternative kdr mutations L1014F and L1014S using allele-specific polymerase chain reaction assays. We recorded the presence of both kdr mutations in northern Indian populations (Alwar and Gurgaon), with the preponderance of L1014S, whereas only L1014F was present in Raipur (central India) and Chennai (southern India). None of the kdr mutations were found in Ranchi in eastern India and in Mangaluru and Mysuru in southern India. This study provides evidence for a focal pattern of distribution of kdr alleles in India.

Item Type: Article
Subjects: Agriculture Biological Sciences > Zoology
University of Mysore > PG Campuses > Manasagangotri, Mysore > Agriculture Biological Sciences > Zoology
Divisions: PG Campuses > Manasagangotri, Mysore > Zoology
Depositing User: Praveen Kumari B.L
Date Deposited: 28 Jun 2017 09:13
Last Modified: 28 Jun 2017 09:13

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