Synthesis and an angiolytic role of novel piperazine–benzothiazole analogues on neovascularization, a chief tumoral parameter in neoplastic development

Al-Ghorbani, Mohammed and Pavankumar, G. S. and Naveen, P. and Thirusangu, Prabhu and Prabhakar, B. T. and Khanum, Shaukath Ara (2016) Synthesis and an angiolytic role of novel piperazine–benzothiazole analogues on neovascularization, a chief tumoral parameter in neoplastic development. Bioorganic Chemistry, 65. pp. 110-117. ISSN 0045-2068

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Official URL: https://doi.org/10.1016/j.bioorg.2016.02.006

Abstract

A novel series of benzoic acid N′-[2-(4-benzothiazol-2-yl-piperazin-1-yl)-acetyl]-hydrazides 6a–j were synthesized and characterized by IR, 1H, 13C NMR, elemental and mass spectral analyses. The in-vitro cytotoxicity and cell viability assay of the synthesized compounds 6a–j were evaluated against Dalton’s lymphoma ascites (DLA) cells. Our results showed that compound 6c with a bromo group on phenyl ring has showed promising antiproliferative efficacy. Further investigation of compound 6c on in-vivo treatment model depicts the increased tumor suppression through inhibition of angiogenesis.

Item Type: Article
Additional Information: Unmapped bibliographic data: PY - 2016/4// [EPrints field already has value set] JO - Bioorganic Chemistry [Field not mapped to EPrints]
Uncontrolled Keywords: Piperazine–benzothiazole, Antiproliferative, Angiogenesis, DLA cells
Subjects: Physical Sciences > Chemistry
Divisions: Constituent Colleges > Yuvaraja's College Mysore > Chemistry
Depositing User: Ms. Manjula p
Date Deposited: 19 May 2017 11:22
Last Modified: 19 May 2017 11:22
URI: http://eprints.uni-mysore.ac.in/id/eprint/19423

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