The antioxidant and antimicrobial activity of the leaves extract of clerodendrum colebrookianum walp, (fam: verbenaceae)

Mahesh, M. and Bagchi, Preenon and Vanchhawng, Lalthanzama and Somashekar, R. and Ravi Shankara, B. E. and Benaka Prasad, S. B. and Richard, S. A. and Dhananjaya, B. L. (2015) The antioxidant and antimicrobial activity of the leaves extract of clerodendrum colebrookianum walp, (fam: verbenaceae). International Journal of Pharmacy and Pharmaceutical Sciences, 7 (1). pp. 96-99. ISSN 0975-1491

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Abstract

Objective: To investigate the in-vitro antioxidant and antimicrobial potential of Clerodendrum colebrookianum leaves extract. Methods: The leaves of C. colebrookianum were collected from various parts of Aizawl, Mizoram, India. Subsequently, the leaves were extracted with solvents (chloroform, acetone, ethanol and methanol) in a Soxhlet extraction apparatus for 24hr. Further, the extracts were extensively examined for its in-vitro antioxidant (DPPH) and antimicrobial activities. The preliminary phytochemical screening was carried out using standard protocols. Results: The existence of alkaloids, flavonoids, diterpenes, saponins, glycosides, steroids and terpeinoids were revealed in the phytochemical screening. The aqueous and acetone extract had the highest total phenolic content (2.348 mg/ml), when compared to methanol, ethanol and chloroform extracts, which was 0.549 mg/ml, 0.408 mg/ml and 0.407 mg/ml, respectively. The antioxidant activity was more significant for aqueous extract, when compared to other extracts. The antimicrobial activity was more significant for acetone extract showed significant zone of inhibition of 14±0.3, 13±0.3 and 15±0.2 for E. coli, S. marcescens and S. aureus, respectively. Conclusion: The high level of antioxidant and antimicrobial potential of C. colebrookianum leaf extracts encourage its potential use for biomedical applications.

Item Type: Article
Subjects: Agriculture Biological Sciences > Biochemistry
University of Mysore > PG Campuses > Manasagangotri, Mysore > Agriculture Biological Sciences > Biochemistry
Divisions: PG Campuses > Manasagangotri, Mysore > Biochemistry
Depositing User: Praveen Kumari B.L
Date Deposited: 27 Dec 2016 10:05
Last Modified: 27 Dec 2016 10:05
URI: http://eprints.uni-mysore.ac.in/id/eprint/19207

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