Anti-Lipoxygenase activity of leaf gall extracts of Terminalia chebula (Gaertn.) Retz. (Combretaceae)

Ravi Shankara, B. E. and Ramachandra, Y. L. and Sundara Rajan, S. and Sujan Ganapathy, P. S. and Austin Richard, S. and Dhananjaya, B. L. (2016) Anti-Lipoxygenase activity of leaf gall extracts of Terminalia chebula (Gaertn.) Retz. (Combretaceae). Pharmacognosy Research, 8 (1). pp. 78-82.

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Official URL: http://dx.doi.org/10.4103/0974-8490.171103

Abstract

Lipoxygenase (LOX) inhibitors are the promising therapeutic target for treating a wide spectrum of inflammatory-related diseases such as cancer, asthma, lymphoma, leukemia, and autoimmune disorders. In the present study, the photochemical constituents and the anti-LOX potential of leaf galls of Terminalia chebula are evaluated to exemplify its further potential development as medicine. Extracts of T. chebula galls were tested for anti-LOX activity using linoleic acid as substrate and lipoxidase as an enzyme and also the total content of polyphenols with phytochemical analysis of the extract were determined. The presence of highest total phenolic and flavonoid content of 141 ± 2.2 mg of gallic acid equivalent/g d.w and 125 ± 1.4 mg of quercetin equivalent/g d.w and maximal LOX inhibitory activity (52.67%) at 800 μg/mL concentrations were identified in the ethanolic extracts of leaf galls of T.chebula. The higher LOX inhibitory activity was positively correlated to the high content of total polyphenols/flavonoids. The results of this study confirm the folklore use of T. chebula leaves gall extracts as a natural anti-inflammatory agent and justify its ethnobotanical use. Therefore, the results encourage the use of T. chebula leave gall extracts for medicinal health, functional food, and nutraceuticals applications.

Item Type: Article
Additional Information: Unmapped bibliographic data: JO - Phcog Res [Field not mapped to EPrints]
Subjects: Agriculture Biological Sciences > Biochemistry
University of Mysore > PG Campuses > Manasagangotri, Mysore > Agriculture Biological Sciences > Biochemistry
Divisions: PG Campuses > Manasagangotri, Mysore > Biochemistry
Depositing User: Praveen Kumari B.L
Date Deposited: 04 May 2016 05:11
Last Modified: 04 May 2016 05:11
URI: http://eprints.uni-mysore.ac.in/id/eprint/18662

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