Copper-catalyzed/mediated synthesis of thiophenes and benzothiophenes: an updated review

Suresh, R. N. and Swaroop, T. R. and Rangappa, K. S. (2026) Copper-catalyzed/mediated synthesis of thiophenes and benzothiophenes: an updated review. Tetrahedron, 191. p. 135089. ISSN 1464-5416

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Abstract

Copper-catalyzed/mediated synthesis of heterocycles plays a crucial role in the field of medicinal chemistry as well as synthetic organic chemistry. Notably, copper salts facilitate the C-S bond formation during the synthesis of heterocycles. On the other hand, they also serve as oxidizing agents, metal catalysts and Lewis acids. This review summarizes an updated collection of copper-catalyzed/mediated synthesis of thiophenes and benzothiophenes. Furthermore, optimal reaction conditions, reaction's scope/generality, pros and/or cons, discussion of control experiments and plausible mechanisms of the reactions are presented. In addition, this review article collects important strategies of copper-catalyzed/mediated synthesis of thiophenes and benzothiophenes reported from 2010 to 2024, which is advantageous for many chemists interested in transition metal-catalyzed reactions.

Item Type:	Article
Uncontrolled Keywords:	Copper, Catalysis, Thiophene, Benzothiophene, Review
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	C Swapna Library Assistant
Date Deposited:	26 Dec 2025 10:28
Last Modified:	26 Dec 2025 10:28
URI:	http://eprints.uni-mysore.ac.in/id/eprint/18237

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