Triazole derivatives as potential antifungal agents: A structure-activity relationship (SAR) studies

Hu, Yuexiao and Liu, Ziwei and Zha, Gaofeng and Long, Sihui and Sridhara, M. B. and Kumar, Kothanahally S. Sharath and Rakesh, Kadalipura P. (2023) Triazole derivatives as potential antifungal agents: A structure-activity relationship (SAR) studies. Process Biochemistry, 135. 102 -118. ISSN 13595113

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Abstract

Today's research is focused on developing new safe drugs of clinical importance. Nitrogen-containing heterocycles are abundant in the common of therapeutic scaffolds. Triazoles are heterocyclic compounds containing a five-membered ring of two carbon atoms and three nitrogen molecules. These structures have sparked enthusiasm for advancing new analogues with miscellaneous biological activities. The need for innovative antifungal drugs is an urgent issue in the current situation where the number of refractory suppressed patients is increasing. This review summarizes research leading to the innovation and progress of latest antifungal agents from a variety of resource during this time. This review primarily focuses on the in vitro and in vivo antifungal activity, design, and SAR of new antifungal agents. © 2023 Elsevier Ltd

Item Type:	Article
Additional Information:	Cited by: 34
Uncontrolled Keywords:	Antifungal agents; Clinical research; Fungicides; Nitrogen; Scaffolds; Antifungal activities; Antifungals; Carbon atoms; Drug discovery; Five-membered rings; Heterocyclic compound; Nitrogen-containing heterocycles; Structure-activity relationships; Triazole; Triazole derivatives; Fungi
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Mr Umendra uom
Date Deposited:	01 Dec 2025 10:49
Last Modified:	01 Dec 2025 10:49
URI:	http://eprints.uni-mysore.ac.in/id/eprint/18157

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