Development of novel indole and coumarin derivatives as antibacterial agents that target histidine kinase in S. aureus

Poonacha, Lisha K. and Ramesh, Rashmi and Ravish, Akshay and Mohan, Arunkumar and Uppar, Pradeep M. and Metri, Prashant K. and Shivananju, Nanjunda Swamy and Gaonkar, Santosh L. and Gopal, Shubha and Sukhorukov, Alexey Yu and Pandey, Vijay and Shubha, Priya Babu and Basappa, Basappa (2023) Development of novel indole and coumarin derivatives as antibacterial agents that target histidine kinase in S. aureus. Applied Microbiology, 3 (4). 1214 -1228. ISSN 26738007

Text (Full Text) Development of Novel Indole and Coumarin Derivatives as Antibacterial Agents That Target Histidine Kinase in S. aureus.pdf - Published Version Download (1MB)

Abstract

Heterocyclic compounds can specifically regulate bacterial development by targeting specific bacterial enzymes and metabolic pathways. The ESKAPE pathogens are multidrug-resistant and cause nosocomial infections, which is one of the greatest challenges in clinical practice. The search for novel agents to combat resistant bacteria has become one of the most important areas of antibacterial research today. Heterocyclic compounds offer a valuable strategy in the fight against resistance as they can be designed to interact with bacterial targets that are less prone to developing resistance mechanisms. Bacterial histidine kinases (HKs), which are a component of two-component bacterial systems, are a promising target for new antibacterial compounds. We have designed and synthesized novel indole derivatives as antibacterial agents. Among the series, indole-coumarin (4b) and bisindole (4e) have shown the best inhibitory activity against S. aureus. Further, in silico docking studies show that compounds 4b and 4e could target histidine kinases in bacteria. © 2023 by the authors.

Item Type:	Article
Additional Information:	Cited by: 2; All Open Access, Gold Open Access
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Mr Umendra uom
Date Deposited:	01 Dec 2025 07:24
Last Modified:	01 Dec 2025 07:24
URI:	http://eprints.uni-mysore.ac.in/id/eprint/18132

Actions (login required)

View Item