Inflammation and oxidative stress in viper bite: an insight within and beyond

Sunitha, K. and Hemshekhar, M. and Thushara, R. M. and Sebastin Santhosh, M. and Shanmuga Sundaram, M. and Kemparaju, K. and Girish, K. S. (2015) Inflammation and oxidative stress in viper bite: an insight within and beyond. Toxicon, 98. pp. 89-97. ISSN 0041-0101

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Official URL: http://dx.doi.org/10.1016/j.toxicon.2015.02.014

Abstract

Though systemic and local manifestations of snakebite are considered serious, the relevance of oxidative stress in viper bite pathology is largely denied. However, over the past decade, studies have provided substantial evidence for the presence of persistent oxidative stress in viper bite victims. This review aims at highlighting the disturbances in redox homeostasis soon after viper envenomation and its implications in the pathomechanism of secondary/long term complications including thrombocytopenia, hypopituitarism, infertility, renal abnormalities and persistent local tissue degradation. Both enzymatic and non-enzymatic components of viper venom play a pivotal role in bringing redox turbulence in victims. Venom-induced hemorrhage and necrosis with subsequent release of damage associated molecular pattern (DAMPs) molecules also contribute to sustained oxidative stress and inflammation. Studies have demonstrated that along with anti-venom therapy an antioxidant treatment during the early stages of viper bite and also long term treatment could help to reduce the occurrence of secondary/long term complications. Further, proper knowledge regarding the pathophysiology will allow for exploration of new avenues in the treatment of viper bite.

Item Type: Article
Additional Information: Unmapped bibliographic data: PY - 2015/5// [EPrints field already has value set] JO - Toxicon [Field not mapped to EPrints]
Uncontrolled Keywords: Viper venom, SVMPs, Hyaluronidase, Oxidative stress, Damage associated molecular patterns (DAMPs), Secondary complications
Subjects: Agriculture Biological Sciences > Biochemistry
University of Mysore > PG Campuses > Manasagangotri, Mysore > Agriculture Biological Sciences > Biochemistry
Divisions: PG Campuses > Manasagangotri, Mysore > Biochemistry
Depositing User: Praveen Kumari B.L
Date Deposited: 21 May 2015 09:03
Last Modified: 21 Nov 2015 10:22
URI: http://eprints.uni-mysore.ac.in/id/eprint/17934

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